Lūkini ʻepekema mai ka State Agrarian University o Novosibirsk, pū me nā hoa hana mai UK mai, no ka manawa mua i kāpae ʻia kahi mea kāohi i hiki ʻole i nā ʻenela nā mea kolo ke pale aku i ka hana o nā fungus parasitic. Hoʻohana ʻia ia ʻano ʻalalā ma ke kumu no nā lāʻau hoʻomalu pest, a ʻo nā hopena o ka noiʻi e kōkua i ka hana ʻana i nā huahana pale mea kanu kū hoʻokahi. O kēia hoike i loko o kahi ʻatikala i paʻi ʻia ma ka puke pai Developmental & Comparative Immunology.
Hiki ke hoʻohana ʻia i ka hoʻomohala ʻana i ka ʻenehana RNAi no nā hoʻolālā hoʻokele pest integrated.
Ke hana nei kahi "lāhui lima" evolution i waena o nā pathogens a me kā lākou mau mea i hōʻino ʻia, e alakaʻi ana i ka puka ʻana o nā loea kūikawā o ka pale a me ka hoʻouka kaua. No laila, hoʻohana ʻia nā fungi parasite no nā mea kolo e like me ka pale ʻana i nā mea kanu mahiʻai i nā mea ʻino. Hiki i kēia mau pulupulu ke hoʻohana i nā enzyme kūikawā, e like me nā proteins haʻihaʻi protease, e komo pono i ka integument o ke kino. Eia nō naʻe, ʻo kekahi mau mea kolo, e komo pū ana me ka moth nui (Galleria mellonella), hoʻokuʻu i nā mea hoʻohiwahiwa protease a me nā kumu pale pale ʻē aʻe e pale ai i ka hoʻouka ʻana o ka maʻi.
I kēia lā, ʻaʻohe mea hōʻike mole mole no ka hana i hiki ʻole ke hōʻole ʻia o ka mea hoʻohālua metalloproteinase insect i ka pale antifungal. E hōʻoia i ka pilina ma waena o nā mea pāpā a me ka pale ʻana i nā fungi, ua hoʻohana nā ʻepekema i ke ʻano o ka hoʻopili ʻana o RNA, ka mea i loko o ka suppression selective o ka hana gen e hoʻohana ana i nā mole liʻiliʻi RNA. Ua ālai nā mea noiʻi i ka hana o kahi mea kāohi lāʻau lapaʻau (IMPI) ma Galleria mellonella a laila hōʻike i nā mea kolo i ka entomopathogenic fungus Metarhizium brunneum.
Ua hoʻemi nui ʻia nā pae IMPI i loko o ka integument (tenfold) a me ke kino adipose (ʻelima mau pā) o nā pepelu i mālama ʻia e RNA i ka hoʻohālikelike ʻia me nā larvae mālama, a ʻoi aku ka nui o ka nui o ka make. No laila, ke pale nei i ka IMPI ma o ka hihia RNA e hōʻino ai i nā pale antifungal a hana i nā mea ʻino ʻino i nā maʻi maʻi.