Mālama ka lolo i nā lysophospholipids o ko mākou kino, a ʻo ia hoʻi e hoʻomalu i kahi papahana e hoʻolalelale ai i ka ʻai meaʻai / nā mea hoʻopaneʻe kikoʻī o ka lipid synthesis hiki ke lilo i mea lapaʻau momona hou / paʻi ʻia ma ka 'Nature Metabolism'.
Ua hoʻomohala kahi hui o nā mea noiʻi i kahi ala hou loa i ka mālama ʻana i nā maʻi ʻai. Ua hōʻike nā ʻepekema ʻo kahi pūʻulu o nā pūnaewele nerve i loko o ka hypothalamus (i kapa ʻia ʻo AgRP, agouti-related peptide neurons) e hoʻomalu i ka hoʻokuʻu ʻana o nā lysophospholipids endogenous, kahi e hoʻomalu ai i ka excitability o nā pūnana nerve i loko o ka cerebral cortex, e hoʻoulu ai i ka ʻai.
Ma kēia kaʻina hana, mālama ʻia ka hana koʻikoʻi o ke ala hōʻailona e ka enzyme autotaxin, nona ke kuleana no ka hana ʻana o ka lysophosphatidic acid (LPA) i loko o ka lolo ma ke ʻano he modulator o ka hana pūnaewele.
ka hooponopono o ka autotaxin inhibitors hiki ke hoʻemi nui i ka nui o ka ʻai ʻana ma hope o ka hoʻokē ʻai a me ka momona i nā ʻano holoholona. Ua ʻike ʻia ka ʻatikala 'AgRP neurons i ka ʻai ʻana i ka meaʻai ma nā cortical synapses ma o nā lysophospholipids peripherally-derived' i kēia manawa ma Nature Metabolism.
ʻO nā maʻi ʻai a ʻoi aku ka nui o ka momona kekahi o nā kumu maʻamau o nā maʻi like ʻole i nā ʻoihana ʻenehana ma ka honua holoʻokoʻa, ʻoi aku ka nui o nā maʻi cardiovascular me ke kino kīnā mau a i ʻole nā hopena make e like me ka hōʻeha puʻuwai, ka maʻi diabetes, a i ʻole ka hahau ʻana.
Ua hōʻike ʻia e ka Robert Koch Institute i ka makahiki 2021 he 67 pakeneka o nā kāne a me 53 pākēneka o nā wahine ma Kelemania he nui ke kaumaha. ʻO 23 pākēneka o ka poʻe mākua ke kaumaha nui loa (obese). ʻO ka hoʻāʻo ʻana e hoʻoikaika i ka ʻai ʻana me ka lāʻau lapaʻau i kēia manawa ʻaʻole pono.
ʻO kahi lāʻau lapaʻau hou e hoʻololi ai i ka hauʻoli o nā ʻupena e hoʻomalu i ka ʻai ʻana he hana koʻikoʻi ia i ka pale ʻana i kēia ʻano momona. Ua ʻike ka hui noiʻi i ka piʻi nui o ka momona a me ka maʻi diabetes type II i nā poʻe me ka hōʻailona LPA synaptic.
ʻO kahi hui i alakaʻi ʻia e Professor Johannes Vogt (Faculty of Medicine, University of Cologne), Professor Robert Nitsch (Faculty of Medicine, University of Münster) a me Professor Thomas Horvath (Yale School of Medicine, New Haven, USA) ua hōʻike i kēia ka mana o ʻO ka hauʻoli o nā neurons i loko o ka cerebral cortex e LPA he kuleana koʻikoʻi i ka mālama ʻana i ka ʻai ʻana: Hoʻoponopono nā neurons AgRP i ka nui o lysophosphatidylcholine (LPC) i loko o ke koko.
Ma o ka lawe ikaika ʻana, hiki i ka LPC i ka lolo, kahi i hoʻololi ʻia e ka enzyme autotaxin (ATX) i LPA, e hana ana ma ka synapse. Hoʻoulu nā hōʻailona LPA Synaptic i nā pūnaewele kikoʻī i ka lolo, no laila ke alakaʻi nei i ka hoʻonui ʻana i ka ʻai.
I ke kŘkohu iole, ma hope o ka manawa o ka hookeai ana i ka pi'i 'ana o ka LPC i loko o ke koko i ho'onui 'ia i ka ho'oulu 'ana i ka LPA ma ka lolo. Hōʻike kēia mau ʻiole i ke ʻano ʻimi ʻai maʻamau. Hiki ke hoʻomaʻamaʻa ʻia nā mea ʻelua e ka hoʻokele autotaxin inhibitors. ʻO nā ʻiole obese, ma ka ʻaoʻao ʻē aʻe, ua lilo ke kaumaha i ka wā i lawelawe mau ʻia ai kēia mau mea hoʻopaneʻe.
ʻO Johannes Vogt, Polofesa ma ke Kula Lapaʻau, Ke Kulanui o Cologne:
"Ua ʻike mākou i kahi hōʻemi nui o ka ʻai ʻana i ka meaʻai nui a me ka momona ma o ka mutation gene a me ka pale ʻana i ka lāʻau lapaʻau o ATX."
"ʻO kā mākou mau ʻike koʻikoʻi e pili ana i ka excitability o ka lolo i hoʻomalu ʻia e ka LPA, a mākou i hana ai no nā makahiki, no laila ke kuleana nui nei no ka ʻai ʻana."
"Ua ʻike mākou i kahi hōʻemi nui o ka ʻai ʻana i ka meaʻai nui a me ka momona ma o ka mutation gene a me ka pale ʻana i ka lāʻau lapaʻau o ATX."
"ʻO kā mākou mau ʻike koʻikoʻi e pili ana i ka excitability o ka lolo i hoʻomalu ʻia e ka LPA, a mākou i hana ai no nā makahiki, no laila ke kuleana nui nei no ka ʻai ʻana."
ʻO Robert Nitsch, Polofesa ma ke Kumu Lapaʻau, Ke Kulanui o Münster:
"Ke hōʻike nei ka ʻikepili i ka poʻe me kahi ala hōʻailona LPA synaptic i hoʻopilikia ʻia e ʻoi aku ka nui o ke kaumaha a loaʻa i ka maʻi diabetes type II."
"He hōʻailona koʻikoʻi kēia o ka kūleʻa therapeutic hiki ke hoʻohana i nā inhibitors ATX, a mākou e hoʻomohala nei me ka Hans Knöll Institute ma Jena no ka hoʻohana ʻana i nā kānaka."
ʻO kēia mau ʻike e pili ana i ka mana hauʻoli o nā ʻupena neuronal i ka ʻai ʻana ma o lysophospholipids a me nā mea hiki ke hoʻōla hou a lākou e manaʻo ai e hiki ke kōkua i ka wā e hiki mai ana i ka mālama ʻana i nā maʻi ʻai, akā i nā maʻi neurological a me nā maʻi psychiatric.